For more Science & Engineering projects click here


This thesis is focused on fabrication of biodegradable implantable devices for extended localized drug release. Paclitaxel (PT) was used as cancer drug in the study. Poly lactic –co- glycolic acid (PLGA) is a polymer used for drug elution. In this work, the role of enzymes on the degradation of PLGA, Effect of different pH on the degradation of PLGA and the kinetics of drug release was elucidated. PLGA ratios of 75:25 and 85:15 were used. The enzyme used in the study is lipase enzyme. The pH used was 4.0, 6.0, 6.5, 7.0 and 7.4. From the study, it was observed that lipase enzyme increased the rate of polymer degradation and thus the rate of drug release from PLGA. This experiment also shows that PLGA degrades faster in acidic medium. This also caused the kinetics of drug release to be higher in acidic medium than in alkaline or neutral medium.

Chapter One
1.0 Introduction

In 2008, the World Health Organization (WHO) estimated all global deaths arising from cancer to be up to 84 million (WHO, 2008). In recent years, the increasing incidence of cancer has been associated with high cancer mortality rates across the globe (WHO, 2014). It was also reported that the different types of cancer causes more deaths than those due to HIV/AIDS, tuberculosis and malaria all combined (WHO, 2014). In any case, early detection and improved treatment are crucial for a successful management of cancer (Anand P et al., 2008). However, it is difficult to detect breast cancer at the early stages. This causes late detection and reduces the chances of effective treatments especially for cases in which the metastatic stage, before detection.

Furthermore, the current cancer treatment methods such as bulk systemic chemotherapy (American Cancer Society (ACS), 2013; Kushi et al., 2012; Parkin et al., 2011; WHO, 2014) and radiotherapy (Gotzsche and Jorgensen, 2013; National Cancer Institute (NCI), 2014) have severe side effects. Such severe side effects can be reduced by a sustained and controlled release of cancer drugs into regions containing cancer cells/tissue (NCI, 2014; WHO 2014). There is, therefore, a strong interest in the localized delivery of cancer drugs from implantable drug delivery systems (NCI, 2014; WHO 2014WHO, 2014; Dubas and Ingraffea, 2013). Recent work focused on the development of implantable non-resolvable systems for cancer drug delivery (ACS, 2014). However, such systems remain in the body, or require surgical removal, after drug release. Hence there is a need for resorbable structures for the controlled release of cancer drugs (Cakir et al., 2012; Jemal et al., 2011; ACS, 2013; WHO, 2014) to tumor regions. Such resorbable structures have been studied over the past decade (ACS, 2014), using biodegradable polymers that facilitate the controlled release of cancer drugs. These include polymers, such as poly (lactic-acid) (PLA) and poly(glycolic-acid) (PGA), and their copolymers (PLGA)

Biodegradable microparticles have also been formulated from PLA or PLGA for controlled drug release (National Cancer Institute, NCI, 2013). PLA or PLGA have also been shown to be biocompatible and biodegradable (NCI 2013; Hanahan and Weinberg, 2000). Furthermore by altering their molecular weight, sample size and surface morphologies (Hanahan and Weinberg, 2011) well-defined degradation rates can be achieved and used to control the release of encapsulated therapeutic agents. This will be explored in the current study of minirods of PLGA that encapsulate PT.The degradation and drug release kinetics are studied using a combination of optical microscopy and UV-Vis spectrophotometry. The implications of the results are also discussed for the development of resorbable/implantable devices for multipulse cancer drug delivery

1.1 Motivation
The use of biodegradable systems are proposed to overcome localized tumours which may lead to the down regulation of receptors or the development of tolerance, while sparing the host tissue from harmful drug concentrations (Jeong and Gutowska., 2002; Soppimath et al, 2002). Such systems would not require any surgical removal once the drug supply is exhausted. The fabrication techniques would involve solvent casting molding of polymeric materials with drug encapsulation. Solvent casting molding method has the advantages of controlling the porosity of samples (scaffolds) (Jeong and Gutowska., 2002) and it is also recommended for heat sensitive drugs (Rabin et al., 2008). Moreover, it is simple to fabricate devices at room temperature as compared to other methods such as compressing molding/melting molding.....

For more Science & Engineering projects click here
This is a Postgraduate Thesis and the complete research material plus questionnaire and references can be obtained at an affordable price of N3,000 within Nigeria or its equivalent in other currencies.


Kindly pay/transfer a total sum of N3,000 into any of our Bank Accounts listed below:
·         Diamond Bank Account:
A/C Name:      Haastrup Francis
A/C No.:         0096144450

·         GTBank Account:
A/C Name:      Haastrup Francis
A/C No.:         0029938679

After payment, send your desired Project Topic, Depositor’s Name, and your Active E-Mail Address to which the material would be sent for downloading (you can request for a downloading link if you don’t have an active email address) to +2348074521866 or +2348066484965. You can as well give us a direct phone call if you wish to. Projects materials are sent in Microsoft format to your mail within 30 Minutes once payment is confirmed. 

N/B:    By ordering for our material means you have read and accepted our Terms and Conditions

Terms of Use: This is an academic paper. Students should NOT copy our materials word to word, as we DO NOT encourage Plagiarism. Only use as guide in developing your original research work.

Delivery Assurance
We are trustworthy and can never SCAM you. Our success story is based on the love and fear for God plus constant referrals from our clients who have benefited from our site. We deliver project materials to your Email address within 15-30 Minutes depending on how fast your payment is acknowledged by us.

Quality Assurance
All research projects, Research Term Papers and Essays on this site are well researched, supervised and approved by lecturers who are intellectuals in their various fields of study.

No comments:

Post a Comment

Note: Only a member of this blog may post a comment.