ANTILIPIDEMIC EFFECT OF WATER (H20) EXTRACT OF DESMODIUM VELUTINUM LEAVES ON ALBINO WISTAR RATS

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ABSTRACT

This study evaluated the antilipidemic activity of water extracts from leaves of Desmodium velutinum on albino wistar rats. The phytochemical analysis of the leaf extract showed the presence of tannins, saponins, alkaloids, soluble carbohydrates, flavonoids, reducing sugar, steroids, cyanide and terpenoids. The animals were treated with known drugs (atorvastatin 2ml). There were significantly reductions in HDL 13.00 1.41 mg/dl LDL 1.20 0.14 mg/dl and triglyceride 39.00 0.14 mg/dl, compared with water extract of Desmodium velutinum (0.5ml). when administered was found to significantly reduce lipid plasma which was LDL 1.90 0.00mg/dl, triglyceride 50.00 0.00mg/dl and increase HDL 25.00 0.00 mg/dl which is the good cholesterol. The water extract of Desmodium velutinum leaf can possibly normalize the plasma lipid when compared with the group given atorvastatin. The phytochemicals analysis showed that the association between these complexes and compounds and other constituent play an important role in the biological activity of the leaf. This study suggested that the water extract of D.velutinum leaf posses hypolipidemic as well as antilipidemic effect.


CHAPTER ONE

INTRODUCTION

1.1            BACKGROUND OF STUDY

Lipid  and  lipoprotein  abnormalities  play  a  major  role  in  the

development and progression of coronary artery diseases. Low levels of high density lipoprotein cholesterols have been identified as independent coronary risk factors (Rodrigue et al., 2010). High level of blood cholesterol is responsible for circulatory system disorder. Increase level of low density lipoprotein (LDL) is alarming for cardiovascular diseases and their risk is increased many times (Harman et al., 2011).

In developing countries, the occurrence of heart diseases increases rapidly (Nordestgard et al., 2010). Medical studies show that about 70% of adults over 50 years old suffer atherosclerosis. (Sherien and Azza, 2009). A large number of synthetic hypolipidemic drugs are available in market. Long term use of these drugs cause serious side effects, and are costly.

A medicinal plant is any plant which in one or more of its organ, contains substance that can be used for therapeutic purpose or which is a precursor for synthesis of useful drugs (Sivakumar et al., 2007). Plant contains a large number of bioactive phytochemicals that.....

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